Journal article
Differential Expression of CD163 on Monocyte Subsets in Healthy and HIV-1 Infected Individuals
E Tippett, WJ Cheng, C Westhorpe, PU Cameron, BJ Brew, SR Lewin, A Jaworowski, SM Crowe
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2011
Abstract
CD163, a haptoglobin-hemoglobin (Hp-Hb) scavenger receptor, expressed by monocytes and macrophages, is important in resolution of inflammation. Age-related non-AIDS co-morbidities in HIV-infected individuals, particularly dementia and cardiovascular disease, result in part from effects of HIV-1 infection on monocyte and macrophage biology. CD163 co-expression on CD14+CD16++ monocytes has been proposed as a useful biomarker for HIV-1 disease progression and the presence of HIV associated dementia. Here we investigated CD163 expression on monocyte subsets ex vivo, on cultured macrophages, and soluble in plasma, in the setting of HIV-1 infection. Whole blood immunophenotyping revealed CD163 exp..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was funded by National Health and Medical Research Council Program Grant 358399 to SRL and SMC. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.